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Gemcitabine-induced systemic capillary leak syndrome.
[systemic capillary leak syndrome]
Systemic
capillary
leak
syndrome
(
SCLS
)
is
a
rare
disorder
with
a
high
mortality
rate
,
characterized
by
rapidly
developing
edema
,
weight
gain
and
hypotension
,
hemoconcentration
and
hypoproteinemia
.
This
syndrome
is
caused
by
sudden
,
reversible
capillary
hyperpermeability
with
a
rapid
extravasation
of
plasma
from
the
intravascular
to
the
interstitial
space
.
Even
though
SCLS
has
been
suggested
to
be
the
pathogenic
mechanism
for
the
pulmonary
toxicity
of
gemcitabine
(
GCB
)
,
a
new
deoxycytidine
analogue
with
structural
similarities
to
cytosine
arabinoside
,
a
direct
correlation
between
GCB
and
SCLS
has
never
been
reported
.
We
describe
a
case
of
repeated
SCLS
after
GCB
administration
in
a
51
-
year
-old
male
with
locally-
advanced
non-
small
-cell
lung
cancer
treated
with
a
combination
of
cisplatin
and
GCB
.
The
detection
of
GCB-induced
SCLS
supports
the
hypothesis
that
SCLS
could
be
the
pathogenic
way
of
GCB
pulmonary
toxicity
.
This
finding
can
help
to
better
understand
and
treat
the
potentially
deadly
GCB-related
acute
respiratory
distress
syndrome
that
is
being
recognized
.
Diseases
Validation
Diseases presenting
"lung cancer"
symptom
adrenal incidentaloma
cholangiocarcinoma
cushing syndrome
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
kindler syndrome
liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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