Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

[systemic capillary leak syndrome]

Capillary leak syndrome (CLS ) commonly occurs in the intensive care setting . CLS is seen in conditions such as septic shock or may result from conditions such as multitrauma and pancreatitis , which result in the systemic inflammatory response syndrome (SIRS ). We present two cases in which both patients suffered with CLS , which we believe was caused following administration of granulocyte colony-stimulating factor , to our knowledge not described in the intensive care patient previously . We discuss how these patients management differs from other intensive care unit patients with CLS and how it is important to diagnose this condition early in haematological oncology cases .