Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience.
[systemic capillary leak syndrome]
Diffuse
myocardial
fibrosis
,
and
to
a
lesser
extent
global
myocardial
edema
,
are
important
processes
in
heart
disease
which
are
difficult
to
assess
or
quantify
with
cardiovascular
magnetic
resonance
(
CMR
)
using
conventional
late
gadolinium
enhancement
(
LGE
)
or
T
1
-
mapping
.
Measurement
of
the
myocardial
extracellular
volume
fraction
(
ECV
)
circumvents
factors
that
confound
T
1
-
weighted
images
or
T
1
-
maps
.
We
hypothesized
that
quantitative
assessment
of
myocardial
ECV
would
be
clinically
useful
for
detecting
both
focal
and
diffuse
myocardial
abnormalities
in
a
variety
of
common
and
uncommon
heart
diseases
.
A
total
of
156
subjects
were
imaged
including
62
with
normal
findings
,
33
patients
with
chronic
myocardial
infarction
(
MI
)
,
33
with
hypertrophic
cardiomyopathy
(
HCM
)
,
15
with
non-ischemic
dilated
cardiomyopathy
(
DCM
)
,
7
with
acute
myocarditis
,
4
with
cardiac
amyloidosis
,
and
2
with
systemic
capillary
leak
syndrome
(
SCLS
)
.
Motion
corrected
ECV
maps
were
generated
automatically
from
T
1
-
maps
acquired
pre-
and
post-contrast
calibrated
by
blood
hematocrit
.
Abnormally
-
elevated
ECV
was
defined
as
>
2
SD
from
the
mean
ECV
in
individuals
with
normal
findings
.
In
HCM
the
size
of
regions
of
LGE
was
quantified
as
the
region
>
2
SD
from
remote
.
Mean
ECV
of
62
normal
individuals
was
25
.
4
±
2
.
5
%
(
m
±
SD
)
,
normal
range
20
.
4
%
-
30
.
4
%
.
Mean
ECV
within
the
core
of
chronic
myocardial
infarctions
(
without
MVO
)
(
N
=
33
)
measured
68
.
5
±
8
.
6
%
(
p
<
0
.
001
vs
normal
)
.
In
HCM
,
the
extent
of
abnormally
elevated
ECV
correlated
to
the
extent
of
LGE
(
r
=
0
.
72
,
p
<
0
.
001
)
but
had
a
systematically
greater
extent
by
ECV
(
mean
difference
19
±
7
%
of
slice
)
.
Abnormally
elevated
ECV
was
identified
in
4
of
16
patients
with
non-ischemic
DCM
(
38
.
1
±
1
.
9
%
(
p
<
0
.
001
vs
normal
)
and
LGE
in
the
same
slice
appeared
"
normal
"
in
2
of
these
4
patients
.
Mean
ECV
values
in
other
disease
entities
ranged
32
-
60
%
for
cardiac
amyloidosis
(
N
=
4
)
,
40
-
41
%
for
systemic
capillary
leak
syndrome
(
N
=
2
)
,
and
39
-
56
%
within
abnormal
regions
affected
by
myocarditis
(
N
=
7
)
.
ECV
mapping
appears
promising
to
complement
LGE
imaging
in
cases
of
more
homogenously
diffuse
disease
.
The
ability
to
display
ECV
maps
in
units
that
are
physiologically
intuitive
and
may
be
interpreted
on
an
absolute
scale
offers
the
potential
for
detection
of
diffuse
disease
and
measurement
of
the
extent
and
severity
of
abnormal
regions
.
Diseases
Validation
Diseases presenting
"diffuse disease"
symptom
systemic capillary leak syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom