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Systemic capillary leak syndrome under general anesthesia: a case report.
[systemic capillary leak syndrome]
Systemic
capillary
leak
syndrome
(
SCLS
)
is
very
rare
and
lethal
disease
and
only
150
cases
have
been
reported
after
the
first
publication
of
its
report
in
1960
by
Clarkson
.
SCLS
is
characterized
by
hemoconcentation
and
hypoalbuminemia
caused
by
reversible
plasma
extravasation
.
Its
mechanism
is
unknown
,
but
transient
dysfunction
of
the
endothelium
is
the
most
suspected
cause
and
trigger
of
this
event
may
cause
immunologic
disarrangement
.
After
recovery
of
endothelial
function
,
fluid
injected
during
the
shock
period
is
redistributed
and
can
cause
severe
pulmonary
edema
.
SCLS
should
be
considered
in
patients
with
acute
and
severe
hypotension
with
hemoconcentration
and
hypoalbuminemia
without
obvious
cardiac
dysfunction
.
Especially
we
should
take
into
account
the
possibility
of
SCLS
if
fluid
replacement
does
not
work
or
the
shock
state
is
aggravated
despite
aggressive
fluid
resuscitation
and
vasopressor
administration
.
SCLS
itself
is
a
very
rare
disease
;
furthermore
,
SCLS
that
develops
during
well-controlled
surgery
is
even
more
rare
.
So
we
report
this
case
with
review
of
the
literature
.
Diseases
Validation
Diseases presenting
"lethal disease"
symptom
adrenomyeloneuropathy
junctional epidermolysis bullosa
megacystis-microcolon-intestinal hypoperistalsis syndrome
systemic capillary leak syndrome
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