Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Sneddon syndrome new clinical and immunological data].
[sneddon syndrome]
In
27
of
47
patients
with
Sneddon
's
syndrome
(
33
females
,
14
males
age
40
years
)
enzyme
immunoassay
has
detected
IgG-antibodies
to
prothrombin
(
aPT
)
-
-
one
of
cofactor
proteins
responsible
for
binding
of
antiphospholipid
antibodies
(
aPL
)
to
phospholipids
.
Other
aPL
were
also
found
:
antibodies
to
cardiolipin
(
aCL
)
,
lupus
anticoagulant
(
LA
)
in
14
and
27
patients
,
respectively
.
37
(
79
%
)
patients
had
at
least
one
of
the
studied
aPL
suggesting
that
such
patients
belong
to
patients
with
primary
antiphospholipid
syndrome
.
A
correlation
exists
between
aPT
and
LA
:
LA
is
detectable
in
67
%
of
aPT-
positive
patients
compared
to
45
%
of
aPT-negative
patients
(
p
<
0
.
05
)
.
This
is
in
agreement
with
the
fact
that
prothrombin
is
a
cofactor
for
most
aPL
registered
as
LA
.
Comparison
of
two
subgroups
of
aPL
patients
different
by
dominant
antigenic
specificity
(
18
patients
with
aPT
but
free
of
ACL
and
6
patients
with
aCP
but
free
of
aPT
)
demonstrated
that
the
latter
developed
disorders
of
cerebral
circulation
,
head
ache
,
dementia
and
renal
syndrome
less
frequently
.
aPT
in
Sneddon
's
syndrome
seems
to
be
a
marker
of
comparatively
low
risk
of
thrombosis
and
less
severe
course
of
the
disease
.
Diseases
Validation
Diseases presenting
"positive patients"
symptom
allergic bronchopulmonary aspergillosis
cadasil
cholangiocarcinoma
cowden syndrome
esophageal squamous cell carcinoma
heparin-induced thrombocytopenia
hodgkin lymphoma, classical
kabuki syndrome
kallmann syndrome
primary effusion lymphoma
sneddon syndrome
typhoid
waldenström macroglobulinemia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom