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[Comparative analysis of clinical and laboratory charactiristics of antiphospholipid syndrome].
[sneddon syndrome]
The
authors
detected
lupus
anticoagulant
and
/
or
anticardiolipin
antibodies
in
1519
patients
'
blood
samples
between
1986
-
1999
in
3rd
Department
of
Internal
Medicine
of
Medical
School
of
Debrecen
.
Examining
only
the
proved
thrombotic
events
and
fetal
losses
as
symptoms
of
antiphospholipid
syndrome
218
patients
had
suffered
from
this
syndrome
.
Secunder
antiphospholipid
syndrome
was
the
diagnosis
in
case
of
420
patients
,
the
most
common
in
Systemic
Lupus
Erythematosus
(
288
patients
)
.
In
704
antiphospholipid
antibody
positivity
cases
the
diagnosis
of
antiphospholipid
syndrome
was
not
fulfilled
.
Analysing
the
antibodies
profile
of
primary
and
secondary
antiphospholipid
syndrome
in
SLE
,
IgG
type
anticardiolipin
antibody
positivity
was
significantly
higher
in
blood
samples
of
SLE
patients
(
82
patients
,
p
<
0
.
01
)
.
Among
thrombotic
manifestations
of
antiphospholipid
syndrome
cerebrovascular
thrombosis
were
significantly
higher
in
patients
suffering
from
SLE
(
128
patients
,
p
<
0
.
04
)
,
while
the
occurrence
of
venous
thrombosis
,
thrombosis
of
coronary
,
carotic
,
aorta
and
peripheral
arteries
and
recurrent
abortions
was
not
significantly
different
in
case
of
primary
and
secondary
antiphospholipid
syndrome
.
Lupus
anticoagulant
positivity
means
higher
risk
for
venous
thrombosis
(
94
patients
,
p
<
0
.
0001
)
,
but
anticardiolipin
antibody
positivity
associated
with
a
higher
risk
for
thrombosis
of
coronary
,
carotic
,
aorta
and
peripheral
arteries
(
59
patients
,
p
<
0
.
00006
)
.
Comparing
IgG-
and
IgM-
type
anticardiolipin
antibody
positivity
the
authors
found
significantly
higher
cerebrovascular
thrombosis
events
in
IgG-anticardiolipin
group
(
p
<
0
.
004
)
.
Sneddon
syndrome
were
detected
in
17
patients
in
the
primary
antiphospholipid
syndrome
group
and
in
16
cases
in
secundary
,
SLE-associated
antiphospholipid
syndrome
group
.
One
of
the
patients
had
died
because
of
the
Catastrophic
Antiphospholipid
Syndrome
.
Diseases
Validation
Diseases presenting
"blood samples"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
adrenomyeloneuropathy
alpha-thalassemia
aniridia
aromatase deficiency
benign recurrent intrahepatic cholestasis
canavan disease
classical phenylketonuria
cohen syndrome
congenital adrenal hyperplasia
congenital toxoplasmosis
cushing syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
fabry disease
familial mediterranean fever
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kallmann syndrome
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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