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Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of livedo vasculitis: a possible involvement of platelet activation.
[sneddon syndrome]
Sneddon
syndrome
is
characterized
by
livedo
reticularis
and
multiple
cerebral
infarctions
.
Skin
and
central
nervous
system
symptoms
usually
have
a
synchronous
onset
and
at
times
initial
symptoms
affect
one
of
them
,
the
other
lagging
several
years
behind
.
We
here
report
a
patient
with
Sneddon
syndrome
who
developed
multiple
cerebral
infarctions
more
than
10
years
after
the
onset
of
livedo
reticularis
.
While
the
neurological
symptoms
were
apparent
,
the
patient
did
not
display
active
skin
manifestations
.
Laboratory
findings
excluded
collagen
diseases
,
antiphospholipid
antibody
syndrome
,
and
inherited
quantitative
deficiency
of
protein
C
,
protein
S
and
antithrombin
III
.
Abnormal
findings
included
extremely
elevated
levels
of
beta
-thromboglobulin
and
platelet
factor
-
4
in
the
blood
,
although
these
acute
phase
markers
of
thrombosis
were
examined
several
years
after
the
onset
of
cerebral
infarctions
.
Platelet
activation
may
have
caused
Sneddon
syndrome
in
the
present
case
.
Diseases
Validation
Diseases presenting
"skin manifestations"
symptom
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
familial mediterranean fever
harlequin ichthyosis
inclusion body myositis
kindler syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
sneddon syndrome
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