Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of livedo vasculitis: a possible involvement of platelet activation.
[sneddon syndrome]
Sneddon
syndrome
is
characterized
by
livedo
reticularis
and
multiple
cerebral
infarctions
.
Skin
and
central
nervous
system
symptoms
usually
have
a
synchronous
onset
and
at
times
initial
symptoms
affect
one
of
them
,
the
other
lagging
several
years
behind
.
We
here
report
a
patient
with
Sneddon
syndrome
who
developed
multiple
cerebral
infarctions
more
than
10
years
after
the
onset
of
livedo
reticularis
.
While
the
neurological
symptoms
were
apparent
,
the
patient
did
not
display
active
skin
manifestations
.
Laboratory
findings
excluded
collagen
diseases
,
antiphospholipid
antibody
syndrome
,
and
inherited
quantitative
deficiency
of
protein
C
,
protein
S
and
antithrombin
III
.
Abnormal
findings
included
extremely
elevated
levels
of
beta
-thromboglobulin
and
platelet
factor
-
4
in
the
blood
,
although
these
acute
phase
markers
of
thrombosis
were
examined
several
years
after
the
onset
of
cerebral
infarctions
.
Platelet
activation
may
have
caused
Sneddon
syndrome
in
the
present
case
.
Diseases
Validation
Diseases presenting
"livedo reticularis"
symptom
malignant atrophic papulosis
sneddon syndrome
This symptom has already been validated