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A random Abstract
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Therapy of Sneddon syndrome.
[sneddon syndrome]
We
report
the
case
of
a
young
woman
with
progressive
cognitive
decline
and
epilepsy
.
She
showed
ischemic
cerebrovascular
disease
and
proximal
livedo
racemosa
.
Antiphospholipid
antibody
(
aPL
)
could
not
be
detected
and
there
were
no
microemboli
on
continuous
transcranial
Doppler
ultrasonography
monitoring
.
Histology
of
cerebral
vessels
showed
intimal
hyperplasia
in
small
leptomeningeal
venous
vessels
and
micronecrosis
of
grey
and
white
matter
.
We
subsequently
made
the
diagnosis
of
aPL-negative
Sneddon
Syndrome
(
SNS
)
.
Anticoagulation
with
warfarin
could
not
be
initiated
because
of
a
drug-resistant
epilepsy
with
the
risk
of
falls
and
subsequent
bleeding
;
immunosuppression
with
steroids
and
azathioprine
was
ineffective
,
as
was
initial
antiplatelet
therapy
with
clopidogrel
alone
.
However
,
when
we
intensified
antiplatelet
therapy
by
combining
clopidogrel
and
ASS
,
a
slowing
of
disease
progression
,
as
assessed
by
neuropsychological
testing
and
magnetic
resonance
imaging
,
was
noted
on
a
follow-up
after
6
months
.
Therapeutic
options
in
SNS
in
both
aPL-
positive
and
aPL-negative
patients
with
SNS
are
discussed
.
Diseases
Validation
Diseases presenting
"epilepsy with the risk"
symptom
sneddon syndrome
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