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The natural course of Sneddon syndrome: clinical and magnetic resonance imaging findings in a prospective six year observation study.
[sneddon syndrome]
Sneddon
syndrome
(
SS
)
is
increasingly
recognised
as
a
cause
of
ischaemic
stroke
in
young
adults
.
As
the
natural
course
of
SS
is
not
well
defined
,
the
authors
performed
a
prospective
six
year
clinical
and
neuroradiological
follow
up
study
.
Thirteen
patients
with
definite
diagnosis
of
SS
(
livedo
racemosa
,
characteristic
skin
biopsy
,
and
history
of
stroke
)
entered
a
follow
up
programme
that
consisted
of
clinical
examinations
,
two
magnetic
resonance
imaging
(
MRI
)
investigations
,
and
a
comprehensive
laboratory
follow
up
protocol
.
The
most
frequent
clinical
findings
during
follow
up
had
been
headache
(
62
%
)
and
vertigo
(
54
%
)
.
Seven
patients
(
54
%
)
suffered
from
transient
ischaemic
attacks
,
however
,
completed
stroke
has
not
been
obtained
during
follow
up
.
Progression
of
white
matter
lesions
detected
in
MRI
were
present
in
10
of
13
patients
.
Laboratory
follow
up
protocol
revealed
transient
antiphospholipid
antibodies
in
two
subjects
.
This
prospective
six
year
follow
up
study
suggests
a
low
incidence
of
territorial
stroke
but
outlines
progressive
leucencephalopathy
in
patients
with
SS
.
Diseases
Validation
Diseases presenting
"transient ischaemic attacks"
symptom
fabry disease
sneddon syndrome
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