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[Non-ischemic neurological manifestations in patients with primary antiphospholipid syndrome].
[sneddon syndrome]
Ischemic
disorders
of
brain
blood
circulation
caused
by
brain
artery
thrombosis
due
to
antiphospholipids-induced
anticoagulopathy
are
main
neurological
appearances
of
primary
antiphospholipid
syndrome
(
PAPS
)
.
A
number
of
neurological
disorders
in
patients
with
PAPS
are
the
result
of
primary
involvement
of
the
brain
and
peripheral
nervous
system
.
We
analyzed
the
spectrum
of
neurological
non-ischemic
PAPS
manifestations
in
125
patients
(
102
female
,
23
male
,
mean
age--
37
.
5
+
/
-
11
.
3
years
)
with
definite
PAPS
.
These
manifestations
included
headache
(
67
%
)
,
epileptic
seizures
(
23
%
)
,
chorea
(
15
%
)
,
optic
neuropathy
(
9
%
)
,
peripheral
neuropathy
(
6
%
)
,
multiple
sclerosis
like
syndrome
(
MSLS
)
(
8
%
)
,
acute
psychosis
(
2
%
)
,
myasthenic
syndrome
(
1
%
)
,
non-
vascular
parkinsonism
(
1
%
)
.
In
the
development
of
non-ischemic
PAPS
manifestations
,
antiphospholipids
as
well
as
other
antibodies
produced
as
a
result
of
immune
disregulation
(
antibodies
to
acetylcholine
receptors
in
myasthenic
syndrome
,
antineuronal
antibodies
in
MSLS
)
may
have
pathogenic
significance
.
In
some
cases
a
role
of
infection
involved
in
PAPS
manifestation
can
not
be
ruled
out
.
Diseases
Validation
Diseases presenting
"peripheral neuropathy"
symptom
adrenomyeloneuropathy
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kallmann syndrome
krabbe disease
neuralgic amyotrophy
oculocutaneous albinism
pyruvate dehydrogenase deficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
waldenström macroglobulinemia
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated
