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[Neurological appearances of primary antiphospholipid syndrome].
[sneddon syndrome]
Neurological
disturbances
frequently
emerge
in
antiphospholipid
syndrome
(
APS
)
.
One
hundred
and
twenty
four
patients
(
100
women
,
24
men
,
mean
age
37
.
5
+
/
-
11
.
3
years
)
with
primary
APS
(
PAPS
)
,
including
76
patients
with
Sneddon
's
syndrome
and
positive
antibodies
to
phospholipids
(
aPL
)
,
have
been
studied
.
A
structure
of
neurological
disturbances
was
as
follows
:
ischemic
lesions
of
cerebral
blood
flow
(
LCBF
)
which
comprised
stroke
and
transient
LCBF
(
91
%
)
;
thrombosis
of
brain
venous
sinuses
(
3
%
)
;
epileptic
seizures
(
24
%
)
;
headache
(
65
%
)
;
chorea
(
15
%
)
;
visual
neuropathy
(
9
%
)
;
peripheral
neuropathy
(
6
%
)
;
multiple
-
sclerosis
-like
syndrome
(
10
%
)
;
myasthenia
syndrome
(
1
%
)
;
syndrome
of
parkinsonism
of
non-
vascular
genesis
(
1
%
)
and
psychotic
disorders
(
2
%
)
.
84
%
patients
had
main
systemic
APS
symptoms
(
fetal
loss
,
thrombosis
)
,
which
preceded
neurological
appearances
in
78
%
cases
.
All
the
patients
had
aPL
:
aPL
to
cardiolipin
(
aCL
)
and
/
or
lupus
coagulant
(
LC
)
and
/
or
aPL
to
phosphatidyl
serine
,
phosphatidyl
inositol
,
phosphatidyl
ethanolamine
.
In
some
patients
,
aCL
titres
ranged
from
positive
to
negative
values
and
LC
was
not
consistently
detected
.
Thus
,
the
presence
of
clinical
symptoms
of
PAPS
including
neurological
disturbances
demands
an
investigation
of
different
aPL
types
as
well
as
a
replicate
study
for
immunological
confirmation
of
PAPS
.
Diseases
Validation
Diseases presenting
"peripheral neuropathy"
symptom
adrenomyeloneuropathy
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kallmann syndrome
krabbe disease
neuralgic amyotrophy
oculocutaneous albinism
pyruvate dehydrogenase deficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
waldenström macroglobulinemia
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated