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Uncoupling of protein C and antithrombin III activity in cerebral ischemia patients associated with cutis marmorata.
[sneddon syndrome]
Cutis
marmorata
is
a
cutaneous
livedoid
disorder
which
can
be
differentiated
from
livedo
reticularis
in
both
clinical
and
pathological
presentations
.
Unlike
Sneddon
syndrome
,
a
detailed
immunocoagulation
profile
has
not
yet
been
delineated
for
cutis
marmorata
in
patients
with
cerebral
ischemia
.
To
analyze
the
immunocoagulation
profile
in
cutis
marmorata
patients
associated
with
cerebral
ischemia
(
CMCI
)
in
a
series
of
135
cerebral
ischemia
patients
.
A
total
of
32
patients
were
found
to
have
cutis
marmorata
.
The
blood
protein
C
activity
,
protein
S
activity
,
antithrombin
III
activity
,
platelet
count
,
fibrinogen
and
frequency
of
abnormal
antiphospholipid
antibody
level
were
similar
among
32
CMCI
patients
,
103
cerebral
ischemia
patients
without
cutis
marmorata
,
and
35
healthy
subjects
.
However
,
uncoupling
of
protein
C
and
anti-thrombin
III
was
observed
in
CMCI
patients
.
Serum
antinuclear
antibody
and
Venereal
Disease
Research
Laboratory
were
not
detected
in
these
patients
.
Cutis
marmorata
is
not
uncommon
in
our
ischemic
stroke
patient
population
,
and
is
characterized
by
uncoupling
of
protein
C
and
antithrombin
III
with
altered
thrombin
hemostasis
.
Our
findings
raise
the
need
for
a
careful
cutaneous
examination
in
patients
with
ischemic
stroke
.
Abnormal
immunocoagulating
profile
should
alert
physicians
to
the
risk
for
cerebral
ischemia
even
in
the
absence
of
other
cardiovascular
risk
factors
.
Diseases
Validation
Diseases presenting
"fibrinogen and frequency of abnormal antiphospholipid antibody level were similar among 32 cmci patients"
symptom
sneddon syndrome
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