Improvement of neurological symptoms and memory and emotional status in a case of seronegative Sneddon syndrome with cyclophosphamide.

[sneddon syndrome]

Sneddon syndrome (SS ) is characterized by livedo racemosa , recurrent ischemic strokes , and often progressive vascular dementia . Treatment options for SS center on either anticoagulation or immunosuppression to prevent strokes and to dissipate the skin findings , with these modalities based historically on the presence or absence of antiphospholipid antibodies (APA ) respectively . However , few effective treatments have been reported to reverse the cognitive decline in SS . We report a case of a woman with seronegative SS (absence of APA ) with cognitive decline who demonstrated objective and subjective improvements in her memory and emotional functioning after treatment with cyclophosphamide .