Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Neurological presentations of the antiphospholipid syndrome: three illustrative cases.
[sneddon syndrome]
The
antiphospholipid
syndrome
(
APS
)
is
defined
by
the
association
of
high
titers
of
antiphospholipid
antibodies
(
aPLs
)
with
thrombotic
events
and
/
or
obstetrical
problems
.
APS
can
be
isolated
or
associated
with
immune
system
diseases
.
Several
central
nervous
system
(
CNS
)
manifestations
have
been
reported
in
APS
,
but
are
still
not
included
in
the
international
diagnostic
criteria
.
We
present
here
three
cases
of
APS
revealed
by
CNS
manifestations
.
The
first
patient
had
a
primary
APS
with
stroke
,
dementia
,
epilepsy
and
the
"
so
-called
"
Liebman-
Sacks
disease
,
a
subacute
thrombotic
non-bacterial
valvulopathy
.
The
second
one
developed
a
primary
APS
with
a
Sneddon
syndrome
,
while
the
third
case
is
a
neurolupus-associated
APS
with
subacute
encephalopathy
,
chorea
,
stroke
,
and
epilepsy
.
The
pathogenesis
of
the
APS
is
related
to
both
prothrombotic
and
immunologic
effects
of
the
aPLs
.
Long
-term
anticoagulation
by
low
-weight
heparin
or
warfarin
is
currently
recommended
in
APS
.
We
propose
to
search
the
presence
of
aPLs
in
any
case
of
young
adults
'
stroke
,
unexplained
dementia
,
and
acquired
chorea
.
Diseases
Validation
Diseases presenting
"dementia"
symptom
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
carcinoma of the gallbladder
cushing syndrome
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
phenylketonuria
sneddon syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated