Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Neurological presentations of the antiphospholipid syndrome: three illustrative cases.
[sneddon syndrome]
The
antiphospholipid
syndrome
(
APS
)
is
defined
by
the
association
of
high
titers
of
antiphospholipid
antibodies
(
aPLs
)
with
thrombotic
events
and
/
or
obstetrical
problems
.
APS
can
be
isolated
or
associated
with
immune
system
diseases
.
Several
central
nervous
system
(
CNS
)
manifestations
have
been
reported
in
APS
,
but
are
still
not
included
in
the
international
diagnostic
criteria
.
We
present
here
three
cases
of
APS
revealed
by
CNS
manifestations
.
The
first
patient
had
a
primary
APS
with
stroke
,
dementia
,
epilepsy
and
the
"
so
-called
"
Liebman-
Sacks
disease
,
a
subacute
thrombotic
non-bacterial
valvulopathy
.
The
second
one
developed
a
primary
APS
with
a
Sneddon
syndrome
,
while
the
third
case
is
a
neurolupus-associated
APS
with
subacute
encephalopathy
,
chorea
,
stroke
,
and
epilepsy
.
The
pathogenesis
of
the
APS
is
related
to
both
prothrombotic
and
immunologic
effects
of
the
aPLs
.
Long
-term
anticoagulation
by
low
-weight
heparin
or
warfarin
is
currently
recommended
in
APS
.
We
propose
to
search
the
presence
of
aPLs
in
any
case
of
young
adults
'
stroke
,
unexplained
dementia
,
and
acquired
chorea
.
Diseases
Validation
Diseases presenting
"chorea"
symptom
acute rheumatic fever
cohen syndrome
sneddon syndrome
This symptom has already been validated