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Neutrophil depletion suppresses pulmonary vascular hyperpermeability and occurrence of pulmonary edema caused by hantavirus infection in C.B-17 SCID mice.
[severe combined immunodeficiency]
Hantavirus
infections
are
characterized
by
vascular
hyperpermeability
and
neutrophilia
.
However
,
the
pathogenesis
of
this
disease
is
poorly
understood
.
Here
,
we
demonstrate
for
the
first
time
that
pulmonary
vascular
permeability
is
increased
by
Hantaan
virus
infection
and
results
in
the
development
of
pulmonary
edema
in
C
.
B-
17
severe
combined
immunodeficiency
(
SCID
)
mice
lacking
functional
T
cells
and
B
cells
.
Increases
in
neutrophils
in
the
lung
and
blood
were
observed
when
pulmonary
edema
began
to
be
observed
in
the
infected
SCID
mice
.
The
occurrence
of
pulmonary
edema
was
inhibited
by
neutrophil
depletion
.
Moreover
,
the
pulmonary
vascular
permeability
was
also
significantly
suppressed
by
neutrophil
depletion
in
the
infected
mice
.
Taken
together
,
the
results
suggest
that
neutrophils
play
an
important
role
in
pulmonary
vascular
hyperpermeability
and
the
occurrence
of
pulmonary
edema
after
hantavirus
infection
in
SCID
mice
.
Although
hantavirus
infections
are
characterized
by
the
occurrence
of
pulmonary
edema
,
the
pathogenic
mechanism
remains
largely
unknown
.
In
this
study
,
we
demonstrated
for
the
first
time
in
vivo
that
hantavirus
infection
increases
pulmonary
vascular
permeability
and
results
in
the
development
of
pulmonary
edema
in
SCID
mice
.
This
novel
mouse
model
for
human
hantavirus
infection
will
be
a
valuable
tool
and
will
contribute
to
elucidation
of
the
pathogenetic
mechanisms
.
Although
the
involvement
of
neutrophils
in
the
pathogenesis
of
hantavirus
infection
has
largely
been
ignored
,
the
results
of
this
study
using
the
mouse
model
suggest
that
neutrophils
are
involved
in
the
vascular
hyperpermeability
and
development
of
pulmonary
edema
in
hantavirus
infection
.
Further
study
of
the
mechanisms
could
lead
to
the
development
of
specific
treatment
for
hantavirus
infection
.
Diseases
Validation
Diseases presenting
"functional t cells"
symptom
severe combined immunodeficiency
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