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Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.
[severe combined immunodeficiency]
Pathogen-
specific
miRNA
profiles
might
reveal
potential
new
avenues
for
therapy
.
To
identify
miRNAs
directly
associated
with
hepatitis
B
virus
(
HBV
)
in
hepatocytes
,
we
performed
a
miRNA
array
analysis
using
urokinase-
type
plasminogen
activator
(
uPA
)
-
severe
combined
immunodeficiency
(
SCID
)
mice
where
the
livers
were
highly
repopulated
with
human
hepatocytes
and
human
immune
cells
are
absent
.
Mice
were
inoculated
with
HBV-infected
patient
serum
samples
.
Eight
weeks
after
HBV
infection
,
human
hepatocytes
were
collected
from
liver
tissues
,
and
miRNAs
were
analysed
using
the
Toray
3
D
array
system
.
The
effect
of
miRNAs
on
HBV
replication
was
analysed
using
HBV-transfected
HepG
2
cells
.
Four
miRNAs
,
hsa-mi
R-
486
-
3
p
,
hsa-mi
R-
1908
,
hsa-mi
R-
675
and
hsa-mi
R-
1231
were
upregulated
in
mouse
and
human
livers
with
HBV
infection
.
These
miRNAs
were
associated
with
immune
response
pathways
such
as
inflammation
mediated
by
chemokine
and
cytokine
signalling
.
Of
these
miRNAs
,
hsa-mi
R-
1231
,
which
showed
high
homology
with
HBV
core
and
HBx
sequences
,
was
most
highly
upregulated
.
In
HBV-transfected
HepG
2
cells
,
overexpression
of
hsa-mi
R-
1231
resulted
in
suppression
of
HBV
replication
with
HBV
core
reduction
.
In
conclusion
,
a
novel
interaction
between
hsa-mi
R-
1231
and
HBV
replication
was
identified
.
This
interaction
might
be
useful
in
developing
new
therapeutic
strategies
against
HBV
.
Diseases
Validation
Diseases presenting
"type plasminogen activator"
symptom
esophageal carcinoma
esophageal squamous cell carcinoma
hereditary cerebral hemorrhage with amyloidosis
severe combined immunodeficiency
wiskott-aldrich syndrome
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