Rare Diseases Symptoms Automatic Extraction

Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?

[severe combined immunodeficiency]

The successful human papillomavirus and hepatitis B virus subunit vaccines contain single viral proteins that represent 22 and 12%, respectively, of the antigens encoded by these tiny viruses. The herpes simplex virus 2 (HSV-2) genome is >20 times larger. Thus, a single protein subunit represents 1% of HSV-2's total antigenic breadth. Antigenic breadth may explain why HSV-2 glycoprotein subunit vaccines have failed in clinical trials, and why live HSV-2 vaccines that express 99% of HSV-2's proteome may be more effective. I review the mounting evidence that live HSV-2 vaccines offer a greater opportunity to stop the spread of genital herpes, and I consider the unfounded 'safety concerns' that have kept live HSV-2 vaccines out of U.S. clinical trials for 25 years.

Diseases presenting "hepatitis" symptom

  • benign recurrent intrahepatic cholestasis
  • cholangiocarcinoma
  • congenital toxoplasmosis
  • dracunculiasis
  • esophageal squamous cell carcinoma
  • hirschsprung disease
  • inclusion body myositis
  • legionellosis
  • neuralgic amyotrophy
  • papillon-lefèvre syndrome
  • primary effusion lymphoma
  • pyomyositis
  • scrub typhus
  • severe combined immunodeficiency
  • typhoid
  • waldenström macroglobulinemia

This symptom has already been validated