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Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy.
[severe combined immunodeficiency]
Patients
undergoing
allogeneic
hematopoietic
stem
cell
transplantation
(
allo-
HSCT
)
are
threatened
by
potentially
lethal
viral
manifestations
like
cytomegalovirus
(
CMV
)
reactivation
.
Because
the
success
of
today
's
virostatic
treatment
is
limited
by
side
effects
and
resistance
development
,
adoptive
transfer
of
virus-
specific
memory
T
cells
derived
from
the
stem
cell
donor
has
been
proposed
as
an
alternative
therapeutic
strategy
.
In
this
context
,
dose
minimization
of
adoptively
transferred
T
cells
might
be
warranted
for
the
avoidance
of
graft-versus-host
disease
(
GVHD
)
,
in
particular
in
prophylactic
settings
after
T
-
cell-depleting
allo-
HSCT
protocols
.
To
establish
a
lower
limit
for
successful
adoptive
T
-
cell
therapy
,
we
conducted
low
-dose
CD
8
(
+
)
T
-
cell
transfers
in
the
well-established
murine
Listeria
monocytogenes
(
L
.
m
.
)
infection
model
.
Major
histocompatibility
complex
-
Streptamer-enriched
antigen-
specific
CD
6
2
L
(
hi
)
but
not
CD
6
2
L
(
lo
)
CD
8
(
+
)
memory
T
cells
proliferated
,
differentiated
,
and
protected
against
L
.
m
.
infections
after
prophylactic
application
.
Even
progenies
derived
from
a
single
CD
6
2
L
(
hi
)
L
.
m
.
-
specific
CD
8
(
+
)
T
cell
could
be
protective
against
bacterial
challenge
.
In
analogy
,
low
-dose
transfers
of
Streptamer-enriched
human
CMV-
specific
CD
8
(
+
)
T
cells
into
allo-
HSCT
recipients
led
to
strong
pathogen-
specific
T
-
cell
expansion
in
a
compassionate-use
setting
.
In
summary
,
low
-dose
adoptive
T
-
cell
transfer
(
ACT
)
could
be
a
promising
strategy
,
particularly
for
prophylactic
treatment
of
infectious
complications
after
allo-
HSCT
.
Diseases
Validation
Diseases presenting
"adoptively transferred t cells"
symptom
severe combined immunodeficiency
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