Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells.
[severe combined immunodeficiency]
Adoptive
immunotherapy
with
antigen-
specific
T
cells
has
shown
promise
for
the
treatment
of
malignancies
.
However
,
infused
T
cells
are
unable
to
redirect
resident
T
cells
,
limiting
potential
benefit
.
While
the
infusion
of
bispecific
T
-
cell
engagers
can
redirect
resident
T
cells
to
tumors
,
these
molecules
have
a
short
half
-life
,
and
do
not
self
amplify
.
To
overcome
these
limitations
,
we
generated
T
cells
expressing
a
secretable
T
-
cell
engager
specific
for
CD
3
and
EphA
2
,
an
antigen
expressed
on
a
broad
range
of
human
tumors
(
EphA
2
-
ENG
T
cells
)
.
EphA
2
-
ENG
T
cells
were
activated
and
recognized
tumor
cells
in
an
antigen-dependent
manner
,
redirected
bystander
T
cells
to
tumor
cells
,
and
had
potent
antitumor
activity
in
glioma
and
lung
cancer
severe
combined
immunodeficiency
(
SCID
)
xenograft
models
associated
with
a
significant
survival
benefit
.
This
new
class
of
tumor
-
specific
T
cells
,
with
the
unique
ability
to
redirect
bystander
T
cells
,
may
be
a
promising
alternative
to
current
immunotherapies
for
cancer
.
Molecular
Therapy
(
2014
)
;
doi
:
10
.
1038
/
mt
.
2014
.
156
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated