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Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
[severe combined immunodeficiency]
Canine
melanoma
is
the
most
common
oral
malignant
tumor
reported
in
the
field
of
veterinary
medicine
.
We
found
that
lupeol
,
a
lupine
triterpene
,
inhibited
mouse
melanoma
cell
growth
in
vitro
and
in
vivo
by
inducing
cell
differentiation
.
In
the
present
study
,
we
examined
the
differentiation-inducing
activities
of
lupeol
on
4
canine
melanoma
cells
in
vitro
and
in
vivo
.
The
induction
of
canine
melanoma
cell
differentiation
by
lupeol
was
confirmed
by
evaluating
some
differentiation
markers
such
as
tyrosinase
with
real-time
RT-PCR
.
Furthermore
,
we
transplanted
canine
melanoma
cells
into
a
severe
combined
immunodeficiency
mouse
,
and
studied
the
anti-
progressive
effects
of
lupeol
on
tumor
tissue
.
The
gene
expression
of
microphthalmia-associated
transcription
factor
,
tyrosinase
,
and
tyrosinase
-related
protein-
2
,
which
are
markers
of
pigment
cell
differentiation
,
was
induced
in
4
canine
oral
malignant
melanoma
cells
by
lupeol
,
and
the
agent
markedly
inhibited
tumor
progression
in
canine
melanoma
-bearing
mice
.
Diseases
Validation
Diseases presenting
"tumor progression"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
dedifferentiated liposarcoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
pleomorphic liposarcoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
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