Rare Diseases Symptoms Automatic Extraction
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Differences in the clinical presentation and the frequency of complications between elderly and non-elderly scrub typhus patients.
[scrub typhus]
Age
can
affect
the
clinical
features
and
severity
of
infectious
disorders
,
such
as
scrub
typhus
.
We
performed
this
study
to
examine
differences
between
elderly
and
non-elderly
scrub
typhus
patients
,
and
to
identify
risk
factors
predictive
of
disease
outcomes
.
This
retrospective
study
included
patients
admitted
to
a
tertiary
hospital
with
scrub
typhus
between
2001
and
2011
.
A
total
of
615
patients
were
enrolled
in
this
study
,
328
of
which
were
>
65
years
of
age
.
Of
the
elderly
patients
,
46
.
0
%
(
151
/
328
)
experienced
at
least
one
complication
compared
to
only
23
.
0
%
(
66
/
287
)
in
younger
patients
.
A
linear
trend
was
observed
between
age
and
complication
rates
(
p
=
0
.
002
)
.
The
most
common
complication
in
elderly
patients
was
acute
kidney
injury
(
75
,
22
.
9
%
)
.
Treatment
failure
was
reported
in
10
elderly
patients
(
3
.
0
%
)
compared
to
one
non-elderly
patient
(
0
.
3
%
)
.
Mental
confusion
and
dyspnea
of
clinical
manifestations
at
admission
were
common
in
elderly
patients
.
Frequency
of
fever
,
rash
,
and
eschar
were
similar
in
both
groups
.
The
following
four
factors
were
significantly
associated
with
severe
scrub
typhus
in
elderly
patients
:
(
1
)
white
blood
cell
(
WBC
)
counts
>
10
,
000
/
mm
(
3
)
(
OR
=
2
.
569
,
CI
=
1
.
298
-
5
.
086
)
,
(
2
)
MDRD
GFR
<
60
mL
/
min
(
OR
=
3
.
525
,
CI
=
1
.
864
-
6
.
667
)
,
(
3
)
albumin
≤
3
.
0
g
/
dL
(
OR
=
4
.
976
,
CI
=
2
.
664
-
9
.
294
)
,
and
(
4
)
acute
physiology
and
chronic
health
evaluation
II
(
APACHE
II
)
score
>
10
points
(
OR
=
3
.
304
,
CI
=
1
.
793
-
60
.
87
)
.
Complications
and
mortality
were
more
common
in
elderly
patients
,
often
associated
with
delays
in
diagnosis
and
treatment
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated