The ketogenic diet: uses in epilepsy and other neurologic illnesses.

[pyruvate dehydrogenase deficiency]

The ketogenic diet is well established as therapy for intractable epilepsy . It should be considered first -line therapy in glucose transporter type 1 and pyruvate dehydrogenase deficiency . It should be considered early in the treatment of Dravet syndrome and myoclonic -astatic epilepsy (Doose syndrome ). Initial studies indicate that the ketogenic diet appears effective in other metabolic conditions , including phosphofructokinase deficiency and glycogenosis type V (McArdle disease ). It appears to function in these disorders by providing an alternative fuel source . A growing body of literature suggests the ketogenic diet may be beneficial in certain neurodegenerative diseases , including Alzheimer disease , Parkinson 's disease , and amyotrophic lateral sclerosis . In these disorders , the ketogenic diet appears to be neuroprotective , promoting enhanced mitochondrial function and rescuing adenosine triphosphate production . Dietary therapy is a promising intervention for cancer , given that it may target the relative inefficiency of tumors in using ketone bodies as an alternative fuel source . The ketogenic diet also may have a role in improving outcomes in trauma and hypoxic injuries .

Diseases
Validation

Diseases presenting "epilepsy" symptom

22q11.2 deletion syndrome

adrenomyeloneuropathy

alexander disease

canavan disease

classical phenylketonuria

cohen syndrome

cowden syndrome

familial hypocalciuric hypercalcemia

gm1 gangliosidosis

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

homocystinuria without methylmalonic aciduria

kabuki syndrome

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neonatal adrenoleukodystrophy

pendred syndrome

phenylketonuria

proteus syndrome

pyruvate dehydrogenase deficiency

sneddon syndrome

wolf-hirschhorn syndrome

zellweger syndrome

This symptom has already been validated