The ketogenic diet: uses in epilepsy and other neurologic illnesses.

[pyruvate dehydrogenase deficiency]

The ketogenic diet is well established as therapy for intractable epilepsy . It should be considered first -line therapy in glucose transporter type 1 and pyruvate dehydrogenase deficiency . It should be considered early in the treatment of Dravet syndrome and myoclonic -astatic epilepsy (Doose syndrome ). Initial studies indicate that the ketogenic diet appears effective in other metabolic conditions , including phosphofructokinase deficiency and glycogenosis type V (McArdle disease ). It appears to function in these disorders by providing an alternative fuel source . A growing body of literature suggests the ketogenic diet may be beneficial in certain neurodegenerative diseases , including Alzheimer disease , Parkinson 's disease , and amyotrophic lateral sclerosis . In these disorders , the ketogenic diet appears to be neuroprotective , promoting enhanced mitochondrial function and rescuing adenosine triphosphate production . Dietary therapy is a promising intervention for cancer , given that it may target the relative inefficiency of tumors in using ketone bodies as an alternative fuel source . The ketogenic diet also may have a role in improving outcomes in trauma and hypoxic injuries .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated