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Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children.
[pyomyositis]
Muscle
side
effects
have
not
been
frequently
assessed
in
childhood
acute
lymphoblastic
leukemia
(
ALL
)
patients
.
Our
objective
was
to
determine
the
early
and
late
muscle
side
effects
during
childhood
ALL
treatment
.
To
this
end
,
we
examined
the
early
muscle
side
effects
in
15
newly
diagnosed
"
therapy
patients
"
(
group
I
)
,
and
the
late
side
effects
in
18
ALL
survivors
"
off
therapy
patients
"
(
group
II
)
.
Muscle
side
effects
were
assessed
by
measuring
hand
grip
strength
(
HGS
)
,
the
"
timed
up
and
go
"
(
TUG
)
test
,
creatine
phosphokinase
,
myoglobin
,
plasma
electrolytes
,
cardiac
troponin
I
before
and
after
induction
chemotherapy
in
group
I
.
The
same
parameters
and
cranial
radiotherapy
dose
were
examined
in
group
II
at
a
single
timepoint
.
Cumulative
doses
of
chemotherapy
were
calculated
,
and
echocardiograms
were
obtained
for
each
group
.
As
a
result
,
we
found
that
the
HGS
and
TUG
measures
of
group
I
at
the
end
of
induction
were
poorer
than
measures
of
the
first
admission
,
control
subjects
,
and
group
II
.
Low
HGS
measures
had
been
normalized
over
time
,
but
the
TUG
measures
remained
poor
.
Overt
rhabdomyolysis
and
pyomyositis
were
not
detected
in
any
of
the
patients
.
These
results
suggested
that
muscle
side
effect
monitoring
might
be
helpful
in
the
follow-up
of
children
with
ALL
.
Diseases
Validation
Diseases presenting
"late muscle side effects"
symptom
pyomyositis
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