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Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children.
[pyomyositis]
Muscle
side
effects
have
not
been
frequently
assessed
in
childhood
acute
lymphoblastic
leukemia
(
ALL
)
patients
.
Our
objective
was
to
determine
the
early
and
late
muscle
side
effects
during
childhood
ALL
treatment
.
To
this
end
,
we
examined
the
early
muscle
side
effects
in
15
newly
diagnosed
"
therapy
patients
"
(
group
I
)
,
and
the
late
side
effects
in
18
ALL
survivors
"
off
therapy
patients
"
(
group
II
)
.
Muscle
side
effects
were
assessed
by
measuring
hand
grip
strength
(
HGS
)
,
the
"
timed
up
and
go
"
(
TUG
)
test
,
creatine
phosphokinase
,
myoglobin
,
plasma
electrolytes
,
cardiac
troponin
I
before
and
after
induction
chemotherapy
in
group
I
.
The
same
parameters
and
cranial
radiotherapy
dose
were
examined
in
group
II
at
a
single
timepoint
.
Cumulative
doses
of
chemotherapy
were
calculated
,
and
echocardiograms
were
obtained
for
each
group
.
As
a
result
,
we
found
that
the
HGS
and
TUG
measures
of
group
I
at
the
end
of
induction
were
poorer
than
measures
of
the
first
admission
,
control
subjects
,
and
group
II
.
Low
HGS
measures
had
been
normalized
over
time
,
but
the
TUG
measures
remained
poor
.
Overt
rhabdomyolysis
and
pyomyositis
were
not
detected
in
any
of
the
patients
.
These
results
suggested
that
muscle
side
effect
monitoring
might
be
helpful
in
the
follow-up
of
children
with
ALL
.
Diseases
Validation
Diseases presenting
"rhabdomyolysis"
symptom
adrenomyeloneuropathy
dystrophic epidermolysis bullosa
focal myositis
inclusion body myositis
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
systemic capillary leak syndrome
This symptom has already been validated