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A random Abstract
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Diverse mechanisms of AKT pathway activation in human malignancy.
[proteus syndrome]
AKT
/
PKB
(
Protein
Kinase
B
)
are
central
proteins
mediating
signals
from
receptor
tyrosine
kinases
and
phosphatidylinositol
3
-
kinase
.
AKT
kinases
are
involved
in
a
number
of
important
cellular
processes
including
cell
proliferation
and
survival
,
cell
size
in
response
to
nutrient
availability
,
tumor
invasion
/
metastasis
,
and
angiogenesis
.
Various
components
of
the
AKT
signaling
pathway
are
encoded
by
tumor
suppressor
genes
and
oncogenes
whose
loss
or
activation
,
respectively
,
plays
an
important
role
in
tumorigenesis
.
The
growing
body
of
evidence
connecting
deregulated
AKT
signaling
with
sporadic
human
cancers
and
inherited
cancer
predisposition
syndromes
is
discussed
.
We
also
highlight
new
findings
regarding
the
involvement
of
activating
mutations
of
AKT
1
,
AKT
2
,
and
AKT
3
in
somatic
overgrowth
disorders
:
Proteus
syndrome
,
hypoglycemia
with
hypertrophy
,
and
hemimegalencephaly
,
respectively
.
In
addition
,
we
review
recent
literature
documenting
the
various
ways
the
AKT
signaling
pathway
is
activated
in
human
cancers
and
consequences
for
molecularly
targeted
therapies
.
Diseases
Validation
Diseases presenting
"respectively"
symptom
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
alpha-thalassemia
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
epidermolysis bullosa simplex
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
harlequin ichthyosis
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
kallmann syndrome
lamellar ichthyosis
liposarcoma
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyruvate dehydrogenase deficiency
scrub typhus
triple a syndrome
von hippel-lindau disease
well-differentiated liposarcoma
wolf-hirschhorn syndrome
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