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A random Abstract
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Developmental disease and cancer: biological and clinical overlaps.
[proteus syndrome]
Numerous
parallelisms
exist
between
development
and
cancer
.
In
this
article
,
I
review
some
of
the
founding
ideas
linking
development
and
cancer
,
and
highlight
clinical
conditions
exhibiting
features
of
both
developmental
derangement
and
cancer
predisposition
,
including
cohesinopathies
,
rasopathies
,
phakomatoses
,
Proteus
syndrome
and
other
overgrowth
disorders
,
recessive
chromosome
breakage
syndromes
,
and
dominant
hereditary
cancer
syndromes
.
I
suggest
that
these
disorders
encompass
a
continuous
spectrum
spanning
clinical
genetics
and
clinical
oncology
,
and
derive
some
general
implications
that
might
be
useful
in
the
future
for
the
treatment
of
these
diseases
.
Diseases
Validation
Diseases presenting
"and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition"
symptom
proteus syndrome
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