Rare Diseases Symptoms Automatic Extraction

Developmental disease and cancer: biological and clinical overlaps.

[proteus syndrome]

Numerous parallelisms exist between development and cancer. In this article, I review some of the founding ideas linking development and cancer, and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition, including cohesinopathies, rasopathies, phakomatoses, Proteus syndrome and other overgrowth disorders, recessive chromosome breakage syndromes, and dominant hereditary cancer syndromes. I suggest that these disorders encompass a continuous spectrum spanning clinical genetics and clinical oncology, and derive some general implications that might be useful in the future for the treatment of these diseases.

Diseases presenting "oncology" symptom

  • adrenal incidentaloma
  • alexander disease
  • aromatase deficiency
  • carcinoma of the gallbladder
  • cholangiocarcinoma
  • coats disease
  • cowden syndrome
  • cutaneous mastocytosis
  • erdheim-chester disease
  • esophageal carcinoma
  • heparin-induced thrombocytopenia
  • hirschsprung disease
  • hodgkin lymphoma, classical
  • oral submucous fibrosis
  • proteus syndrome
  • systemic capillary leak syndrome

This symptom has already been validated