Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: a community-based survey and hematologic features.

[alpha-thalassemia]

A community-based survey was conducted to determine the prevalence and gene frequency of Hemoglobin Constant Spring (Hb CS ) and other forms of thalassemia among an ethnic minority in Vietnam . A total of 298 ethnic minority women , the C ó-Tu , participated . Hematological parameters and hemoglobin profiles were analyzed using standard automated analyzers . Alpha - and beta-thalassemia mutations were identified using polymerase chain reaction (PCR ) based technology . Of the 298 women , 141 (47 .3 %) carried thalassemia genes . Hemoglobin Constant Spring (Hb CS ) is the most common with a markedly high frequency of 0 .143 (overall prevalence =26 .2 %). The heterozygous state of Hb CS was found in one -fifth (20 .5 %) of women participating . Seven women (2 .4 %) were Hb CS homozygote . The overall prevalence for Hb E was 13 .8 %, and 10 .7 % for α (+)-thalassemia . Other forms of thalassemia included 0 .67 % β-thalassemia , and 0 .34 % Hb Paksé . None of the participants had the α (0 )-thalassemia gene . The study provides basic epidemiological information about Hb CS as well as other forms of thalassemia for a specific group of an ethnic minority in Vietnam . The data will be useful for further study on the distribution of thalassemia in Southeast Asia .

Diseases
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Diseases presenting "specific group of an ethnic minority" symptom

alpha-thalassemia

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