Self-limited effusion large B-cell lymphoma: two cases of effusion lymphoma maintaining remission after drainage alone.

[primary effusion lymphoma]

We report two cases of human herpesvirus-8 (HHV-8 )-negative large B-cell lymphoma involving pericardial and /or pleural effusion that regressed after drainage alone . Case 1 is a 70 -year -old man showing massive pericardial effusion . Cytology of the drained effusion showed monotonous infiltration of CD 3 -, CD 2 0 +, CD 7 9 a +, and CD 138 - large B-cells . Monoclonality was shown by Southern blot analysis . Case 2 is a 70 -year -old man with massive pericardial and bilateral pleural effusion . Cytology of pericardial effusion showed infiltration of CD 2 0 +, CD 4 5 RO -, CD 138 -, immunoglobulin lambda chain +, and kappa chain- large B cells . In both cases , effusion resolved after drainage and no relapse has been observed . HHV-8 was not demonstrated in either case . Clinical presentation of our two cases resembled primary effusion lymphoma (PEL ), but cytomorphology , immunophenotype , and prognosis were clearly distinct from those of PEL . HHV-8 -negative effusion lymphomas might include prognostically favorable self-limited tumors that could regress without any cytotoxic therapy .

Diseases
Validation

Diseases presenting "lymphoma" symptom

adrenal incidentaloma

alpha-thalassemia

carcinoma of the gallbladder

cushing syndrome

dedifferentiated liposarcoma

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

familial hypocalciuric hypercalcemia

focal myositis

hirschsprung disease

hodgkin lymphoma, classical

kabuki syndrome

liposarcoma

locked-in syndrome

monosomy 21

oculocutaneous albinism

primary effusion lymphoma

severe combined immunodeficiency

systemic capillary leak syndrome

waldenström macroglobulinemia

wiskott-aldrich syndrome

This symptom has already been validated