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Self-limited effusion large B-cell lymphoma: two cases of effusion lymphoma maintaining remission after drainage alone.
[primary effusion lymphoma]
We
report
two
cases
of
human
herpesvirus-
8
(
HHV-
8
)
-
negative
large
B-
cell
lymphoma
involving
pericardial
and
/
or
pleural
effusion
that
regressed
after
drainage
alone
.
Case
1
is
a
70
-
year
-old
man
showing
massive
pericardial
effusion
.
Cytology
of
the
drained
effusion
showed
monotonous
infiltration
of
CD
3
-
,
CD
2
0
+
,
CD
7
9
a
+
,
and
CD
138
-
large
B-
cells
.
Monoclonality
was
shown
by
Southern
blot
analysis
.
Case
2
is
a
70
-
year
-old
man
with
massive
pericardial
and
bilateral
pleural
effusion
.
Cytology
of
pericardial
effusion
showed
infiltration
of
CD
2
0
+
,
CD
4
5
RO
-
,
CD
138
-
,
immunoglobulin
lambda
chain
+
,
and
kappa
chain-
large
B
cells
.
In
both
cases
,
effusion
resolved
after
drainage
and
no
relapse
has
been
observed
.
HHV-
8
was
not
demonstrated
in
either
case
.
Clinical
presentation
of
our
two
cases
resembled
primary
effusion
lymphoma
(
PEL
)
,
but
cytomorphology
,
immunophenotype
,
and
prognosis
were
clearly
distinct
from
those
of
PEL
.
HHV-
8
-
negative
effusion
lymphomas
might
include
prognostically
favorable
self-
limited
tumors
that
could
regress
without
any
cytotoxic
therapy
.
Diseases
Validation
Diseases presenting
"bilateral pleural effusion"
symptom
dedifferentiated liposarcoma
primary effusion lymphoma
scrub typhus
systemic capillary leak syndrome
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