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[Investigation of HHV-8 prevalence in anti-HIV-1 positive patients in Istanbul, Turkey].
[primary effusion lymphoma]
Human
herpes
virus-
8
(
HHV-
8
)
infections
are
associated
with
Kaposi
's
Sarcoma
(
KS
)
,
Multiple
Castleman
disease
and
primary
effusion
lymphoma
,
and
particularly
important
in
HIV
/
AIDS
and
transplantation
patients
.
The
aim
of
this
prospective
study
was
to
detect
HHV-
8
prevalence
in
HIV-
1
-
infected
patients
,
in
a
Turkish
population
.
A
total
of
85
anti-
HIV-
1
positive
patients
(
53
male
,
32
female
;
age
range
:
1
-
70
years
)
diagnosed
at
Istanbul
Faculty
of
Medicine
,
Infectious
Diseases
and
Clinical
Microbiology
Department
were
included
in
the
study
.
In
45
(
53
%
)
of
the
patients
HIV-RNA
was
detectable
and
viral
loads
were
between
20
-
10
.
000
.
000
copies
/
ml
.
HHV-
8
-
specific
IgG
antibodies
were
screened
by
using
a
commercial
ELISA
kit
(
Advanced
Biotechnologies
Inc
,
USA
)
,
and
the
presence
of
HHV-
8
nucleic
acids
were
investigated
by
PCR
(
Roche
Diagnostics
,
Germany
)
in
the
blood
samples
obtained
from
patients
.
HHV-
8
IgG
was
detected
in
28
.
2
%
(
24
/
85
)
of
the
anti-
HIV-
1
positive
patients
,
and
HHV-
8
DNA
was
detected
in
3
.
5
%
(
3
/
85
)
.
One
of
the
three
HHV-
8
DNA
positive
cases
was
seropositive
as
well
.
Twenty
-
five
percent
of
the
seropositive
patients
were
female
(
6
/
24
)
and
75
%
were
male
(
18
/
24
)
.
Of
three
HHV-
8
DNA
positive
cases
,
two
were
male
and
one
was
female
.
The
distribution
of
HHV-
8
seropositivity
rates
according
to
the
age
groups
were
as
follows
;
1
/
3
for
1
-
10
years
,
1
/
2
for
11
-
20
years
,
3
/
8
for
21
-
30
years
,
7
/
27
for
31
-
40
years
,
9
/
30
for
41
-
50
years
,
1
/
9
for
51
-
60
years
,
and
2
/
6
for
61
-
70
years
.
The
highest
seropositivity
rate
was
detected
in
41
-
50
age
group
(
9
/
24
,
37
.
5
%
)
,
followed
by
31
-
40
age
group
(
7
/
24
,
29
.
2
%
)
,
presenting
statistically
significant
differences
between
the
other
age
groups
(
p
<
0
.
05
)
.
HHV-
8
DNA
was
detected
in
only
1
(
4
.
2
%
)
out
of
24
IgG
seropositive
patients
.
HIV
viral
loads
of
the
two
HHV-
8
seronegative
patients
whose
HHV-
8
DNA
levels
of
<
500
copy
/
ml
,
were
<
20
copy
/
ml
and
1250
copy
/
ml
,
respectively
.
HIV-RNA
load
of
the
other
patient
with
HHV-
8
IgG
positivity
and
2240
copy
/
ml
of
HHV-
8
DNA
,
was
191
.
000
copy
/
ml
.
None
of
the
HIV-
1
positive
patients
presented
with
clinical
symptoms
for
KS
.
However
,
clinical
and
virological
follow-up
of
those
cases
with
HHV-
8
IgG
and
/
or
DNA
positivity
would
be
useful
to
predict
and
control
of
a
possible
development
of
KS
or
other
HHV-
8
-
related
pathologies
.
For
a
more
comprehensive
understanding
of
HHV-
8
epidemiology
in
Turkey
,
multicentre
studies
with
higher
number
of
cases
are
needed
.
Diseases
Validation
Diseases presenting
"positive cases"
symptom
aromatase deficiency
congenital adrenal hyperplasia
congenital toxoplasmosis
dedifferentiated liposarcoma
esophageal adenocarcinoma
esophageal squamous cell carcinoma
heparin-induced thrombocytopenia
hodgkin lymphoma, classical
kabuki syndrome
primary effusion lymphoma
scrub typhus
typhoid
well-differentiated liposarcoma
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