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Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition.
[primary effusion lymphoma]
The
introduction
of
combined
antiretroviral
therapy
(
ART
)
has
reduced
the
mortality
of
patients
with
human
immunodeficiency
virus-
1
infection
worldwide
.
However
,
malignant
lymphoma
is
a
severe
and
frequent
complication
seen
in
patients
with
acquired
immunodeficiency
syndrome
(
AIDS
)
.
The
diagnostic
criteria
for
some
categories
of
AIDS-related
lymphoma
were
revised
in
the
World
Health
Organization
International
Classification
of
Lymphoma
,
fourth
edition
.
The
purpose
of
this
study
was
to
assess
the
clinicopathological
characteristics
of
Japanese
patients
with
AIDS-related
lymphoma
according
to
the
revised
classification
.
In
this
retrospective
study
,
207
AIDS-related
lymphoma
cases
diagnosed
between
1987
and
2012
in
Japan
were
subjected
to
histological
subtyping
and
clinicopathological
analyses
.
Diffuse
large
B-
cell
lymphoma
(
DLBCL
)
was
the
predominant
histological
subtype
throughout
the
study
period
(
n
=
104
,
50
%
)
.
Among
the
DLBCL
cases
,
24
%
were
of
the
germinal
center
(
GC
)
type
and
76
%
were
of
the
non-
GC
type
.
Non-
GC
-
type
cases
showed
a
significantly
lower
1
-
year
survival
rate
(
43
%
)
than
the
GC
-
type
cases
(
82
%
)
.
Cases
of
Burkitt
lymphoma
(
n
=
57
,
28
%
)
,
plasmablastic
lymphoma
(
n
=
16
,
8
%
)
,
primary
effusion
lymphoma
(
n
=
9
,
4
%
)
,
Hodgkin
lymphoma
(
n
=
8
,
4
%
)
,
and
large
B-
cell
lymphoma
arising
in
Kaposi
sarcoma
-associated
herpesvirus-associated
multicentric
Castleman
disease
(
n
=
2
,
1
%
)
were
also
observed
.
Hodgkin
lymphoma
was
more
common
in
patients
receiving
ART
(
11
.
1
%
)
than
in
ART-naïve
patients
(
1
.
4
%
)
.
Statistical
analyses
identified
CD
10
negativity
,
BCL-
6
negativity
,
Epstein-
Barr
virus
positivity
,
and
Kaposi
sarcoma
-associated
herpesvirus
positivity
as
risk
factors
for
poor
prognosis
.
This
information
will
help
in
the
early
diagnosis
of
lymphoma
in
patients
with
AIDS
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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