HHV-8 seroprevalence: a global view.

[primary effusion lymphoma]

Human herpes virus 8 (HHV-8 ) is the underlying infectious cause of Kaposi sarcoma (KS ) and other proliferative diseases ; that is , primary effusion lymphoma and multicentric Castleman disease . In regions with high HHV-8 seroprevalence in the general population , KS accounts for a major burden of disease . Outside these endemic regions , HHV-8 prevalence is high in men who have sex with men (MSM ) and in migrants from endemic regions . We aim to conduct a systematic literature review and meta -analysis in order 1 ) to define the global distribution of HHV-8 seroprevalence (primary objective ) and 2 ) to identify risk factors for HHV-8 infection , with a focus on HIV status (secondary objective ).We will include observational studies reporting data on seroprevalence of HHV-8 in children and /or adults from any region in the world . Case reports and case series as well as any studies with fewer than 50 participants will be excluded . We will search MEDLINE , EMBASE , and relevant conference proceedings without language restriction . Two reviewers will independently screen the identified studies and extract data on study characteristics and quality , study population , risk factors , and reported outcomes , using a standardized form . For the primary objective we will pool the data using a fully bayesian approach for meta -analysis , with random effects at the study level . For the secondary objective (association of HIV and HHV-8 ) we aim to pool odds ratios for the association of HIV and HHV-8 using a fully bayesian approach for meta -analysis , with random effects at the study level . Sub-group analyses and meta -regression analyses will be used to explore sources of heterogeneity , including factors such as geographical region , calendar years of recruitment , age , gender , ethnicity , socioeconomic status , different risk groups for sexually and parenterally transmitted infections (MSM , sex workers , hemophiliacs , intravenous drug users ), comorbidities such as organ transplantation and malaria , test (s ) used to measure HHV-8 infection , study design , and study quality .Using the proposed systematic review and meta -analysis , we aim to better define the global seroprevalence of HHV-8 and its associated risk factors . This will improve the current understanding of HHV-8 epidemiology , and could suggest measures to prevent HHV-8 infection and to reduce its associated cancer burden .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated