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Primary effusion lymphoma: secretome analysis reveals novel candidate biomarkers with potential pathogenetic significance.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
a
rare
B-
cell
neoplasm
in
which
tumor
cells
are
consistently
infected
by
Kaposi
's
sarcoma
-associated
herpesvirus
and
usually
grow
in
body
cavities
without
tumor
mass
formation
.
To
detect
new
proteins
related
to
pathogenesis
,
four
established
cell
lines
from
PEL
(
CRO-
AP
2
,
CRO-
AP
3
,
CRO-
AP
5
,
and
CRO-
AP
6
)
were
characterized
by
proteomics
analysis
of
the
secretome
.
The
secretomes
were
analyzed
using
two
complementary
mass
spectrometry
platforms
:
liquid
chromatography-mass
spectrometry
and
matrix-assisted
laser
desorption
/
ionization
time-of-flight-based
approaches
.
Among
266
proteins
identified
from
the
proteomics
analysis
,
139
were
considered
as
predicted
secreted
.
Twenty
proteins
were
specifically
secreted
by
PEL
cell
lines
after
comparison
with
secretomes
of
human
cell
lines
representative
of
diverse
solid
tumors
and
leukemias
.
More
important
,
27
additional
proteins
were
shared
by
all
CRO-
AP
PEL
cell
lines
.
The
presence
of
these
proteins
was
confirmed
by
IHC
in
CRO-
AP
cell
lines
and
in
six
other
PEL
cell
lines
,
four
PEL
clinical
samples
,
and
three
extracavitary
Kaposi
's
sarcoma
-associated
herpesvirus-
positive
solid
lymphomas
included
for
comparative
analysis
.
Functional
classification
showed
that
PEL
cell
secretomes
were
enriched
in
proteins
specifically
involved
in
inflammation
/
immune
response
,
growth
/
cell
cycle
,
and
mRNA
processing
,
in
addition
to
structural
/
matrix
proteins
and
proteins
with
enzymatic
activity
.
Diseases
Validation
Diseases presenting
"neoplasm"
symptom
adrenal incidentaloma
alexander disease
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hodgkin lymphoma, classical
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated