Primary effusion lymphoma-like lymphoma in a patient with inflammatory bowel disease.

[primary effusion lymphoma]

A 77 -year -old man with inflammatory bowel disease (IBD ) and who was treated with anti-tumor necrosis factor (TNF ), 6 -mercaptopurine and corticosteroids , presented with primary effusion lymphoma -like lymphoma (PEL -like lymphoma ) with massive ascites . The patient 's clinical course was complicated by acute renal insufficiency and hypotension , which led to death within 2 wk . In general , patients with IBD may have an increased risk for development of lymphoma , which is frequently associated with immunosuppressive and /or anti-TNF antibody therapies . PEL is a rare subset of lymphoma localized to serous body cavities , lacks tumor mass or nodal involvement , and is associated with infection by human herpes virus 8 (HHV-8 ). Primary neoplastic effusion may also be present in patients with large B-cell lymphoma without evidence of human immunodeficiency virus or HHV-8 infections . This type of lymphoma is classified as PEL -like lymphoma . Both PEL and PEL -like lymphoma types have been reported in patients undergoing immunosuppressive therapy , but to the best of our knowledge , the case described herein represents the first PEL -like lymphoma occurring in a patient with IBD .

Diseases
Validation

Diseases presenting "hypotension" symptom

achondroplasia

adrenal incidentaloma

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cutaneous mastocytosis

fabry disease

familial mediterranean fever

primary effusion lymphoma

scrub typhus

systemic capillary leak syndrome

thoracic outlet syndrome

typhoid

This symptom has already been validated