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Systematic analysis of a xenograft mice model for KSHV+ primary effusion lymphoma (PEL).
[primary effusion lymphoma]
Kaposi
's
sarcoma
-associated
herpesvirus
is
the
causative
agent
of
primary
effusion
lymphoma
(
PEL
)
,
which
arises
preferentially
in
the
setting
of
infection
with
human
immunodeficiency
virus
(
HIV
)
.
Even
with
standard
cytotoxic
chemotherapy
,
PEL
continues
to
cause
high
mortality
rates
,
requiring
the
development
of
novel
therapeutic
strategies
.
PEL
xenograft
models
employing
immunodeficient
mice
have
been
used
to
study
the
in
vivo
effects
of
a
variety
of
therapeutic
approaches
.
However
,
it
remains
unclear
whether
these
xenograft
models
entirely
reflect
clinical
presentations
of
KSHV
(
+
)
PEL
,
especially
given
the
recent
description
of
extracavitary
solid
tumor
variants
arising
in
patients
.
In
addition
,
effusion
and
solid
tumor
cells
propagated
in
vivo
exhibit
unique
biology
,
differing
from
one
another
or
from
their
parental
cell
lines
propagated
through
in
vitro
culture
.
Therefore
,
we
used
a
KSHV
(
+
)
PEL
/
BCBL-
1
xenograft
model
involving
non-obese
diabetic
/
severe
-combined
immunodeficient
(
NOD
/
SCID
)
mice
,
and
compared
characteristics
of
effusion
and
solid
tumors
with
their
parent
cell
culture-derived
counterparts
.
Our
results
indicate
that
although
this
xenograft
model
can
be
used
for
study
of
effusion
and
solid
lymphoma
observed
in
patients
,
tumor
cells
in
vivo
display
unique
features
to
those
passed
in
vitro
,
including
viral
lytic
gene
expression
profile
,
rate
of
solid
tumor
development
,
the
host
proteins
and
the
complex
of
tumor
microenvironment
.
These
items
should
be
carefully
considered
when
the
xenograft
model
is
used
for
testing
novel
therapeutic
strategies
against
KSHV-related
lymphoma
.
Diseases
Validation
Diseases presenting
"extracavitary solid tumor variants"
symptom
primary effusion lymphoma
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