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Primary effusion lymphoma with aberrant T-cell phenotype in an iatrogenically immunosuppressed renal transplant male: Cytologic diagnosis in peritoneal fluid.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
an
unusual
class
of
non-
Hodgkin
's
lymphoma
that
develops
in
body
cavities
,
without
associated
mass
lesions
.
It
has
been
linked
to
human
herpes
virus
8
(
HHV-
8
)
,
an
etiological
factor
of
Kaposi
's
sarcoma
.
Although
PEL
is
a
B-
cell
lymphoma
,
the
neoplastic
cells
are
usually
of
the
"
null
"
phenotype
by
immunocytochemistry
.
The
relative
infrequency
of
this
entity
,
the
absence
of
wide
casuistic
allowing
a
better
characterization
,
and
its
unfavorable
outcome
,
strongly
support
the
need
of
a
deeper
knowledge
.
We
report
the
clinico-biological
findings
of
a
49
-
year
-old
male
who
was
iatrogenically
suppressed
patient
for
29
years
because
of
renal
transplantation
.
This
case
was
diagnosed
cytologically
as
peritoneal
PEL
and
confirmed
histologically
on
peritoneal
biopsies
.
The
immune
status
for
both
HHV-
8
and
Epstein-
Barr
virus
(
EBV
)
was
evaluated
and
showed
positive
immunostaining
only
for
the
former
.
The
combination
of
the
immunocytochemistry
results
with
the
existence
of
a
clonal
rearrangement
in
the
immunoglobulin
heavy
chain
gene
(
identified
by
PCR
)
was
compatible
with
the
diagnosis
of
PEL
.
The
presence
of
T
-
cell
markers
was
consistent
with
the
diagnosis
of
PEL
with
an
aberrant
T
-
cell
phenotype
.
Diagn
.
Cytopathol
.
2014
.
©
2014
Wiley
Periodicals
,
Inc
.
Diseases
Validation
Diseases presenting
"suppressed patient for 29 years"
symptom
primary effusion lymphoma
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