Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis: A case report.

[primary effusion lymphoma]

This study describes a rare case of Human Immunodeficiency Virus and Human Herpes Virus 8 (HHV-8 ) negative primary effusion lymphoma (PEL )-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis , diagnosed in a 66 -year -old male who rapidly progressed to a sense of abdominal fullness . Cytological analysis of the pleural effusion demonstrated large atypical lymphoid cells with rounded nuclei , prominent nucleoli , and abundant cytoplasm . Immunocytochemistry of the pleural effusion detected atypical CD 2 0 (+) lymphoid cells . The patient was hospitalized , and died following sepsis and multi-organ failure . Our case highlights that HHV-8 -unrelated PEL -like lymphoma patients have different pathogenetic mechanisms of causality at the biological level , immunophenotype , clinical behavior , and prognosis .