Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells.

[primary effusion lymphoma]

Primary effusion lymphoma (PEL ), associated with the latent infection by KSHV , constitutively expresses interferon-regulatory factor 4 (IRF 4 ). We recently showed that IRF 4 differentially regulates expression of cellular interferon-stimulated genes (ISGs ) and viral genes (Forero et al ., 2013 ). Here , using inducible IRF 4 knockdown , we demonstrate that IRF 4 silencing results in enhanced transcription of KSHV replication transactivator RTA . As a result viral transcription is increased leading to virus reactivation . Taken together , our results show that IRF 4 helps maintain the balance between latency and KSHV reactivation in PEL cells .

Diseases
Validation

Diseases presenting "lymphoma" symptom

adrenal incidentaloma

alpha-thalassemia

carcinoma of the gallbladder

cushing syndrome

dedifferentiated liposarcoma

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

familial hypocalciuric hypercalcemia

focal myositis

hirschsprung disease

hodgkin lymphoma, classical

kabuki syndrome

liposarcoma

locked-in syndrome

monosomy 21

oculocutaneous albinism

primary effusion lymphoma

severe combined immunodeficiency

systemic capillary leak syndrome

waldenström macroglobulinemia

wiskott-aldrich syndrome

This symptom has already been validated