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Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis.
[primary effusion lymphoma]
Human
herpesvirus
8
(
HHV-
8
;
Kaposi
's
sarcoma
-associated
herpesvirus
)
is
an
oncogenic
gammaherpesvirus
that
primarily
infects
cells
of
the
immune
and
vascular
systems
.
HHV-
8
interacts
with
and
targets
professional
antigen
presenting
cells
and
influences
their
function
.
Infection
alters
the
maturation
,
antigen
presentation
,
and
immune
activation
capabilities
of
certain
dendritic
cells
(
DC
)
despite
non-robust
lytic
replication
in
these
cells
.
DC
sustains
a
low
level
of
antiviral
functionality
during
HHV-
8
infection
in
vitro
.
This
may
explain
the
ability
of
healthy
individuals
to
effectively
control
this
virus
without
disease
.
Following
an
immune
compromising
event
,
such
as
organ
transplantation
or
human
immunodeficiency
virus
type
1
infection
,
a
reduced
cellular
antiviral
response
against
HHV-
8
compounded
with
skewed
DC
cytokine
production
and
antigen
presentation
likely
contributes
to
the
development
of
HHV-
8
associated
diseases
,
i
.
e
.
,
Kaposi
's
sarcoma
and
certain
B
cell
lymphomas
.
In
this
review
we
focus
on
the
role
of
DC
in
the
establishment
of
HHV-
8
primary
and
latent
infection
,
the
functional
state
of
DC
during
HHV-
8
infection
,
and
the
current
understanding
of
the
factors
influencing
virus-
DC
interactions
in
the
context
of
HHV-
8
-
associated
disease
.
Diseases
Validation
Diseases presenting
"immunodeficiency"
symptom
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
cushing syndrome
dracunculiasis
hirschsprung disease
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kabuki syndrome
legionellosis
malignant atrophic papulosis
oculocutaneous albinism
omenn syndrome
papillon-lefèvre syndrome
primary effusion lymphoma
primary hyperoxaluria type 1
pyomyositis
severe combined immunodeficiency
sneddon syndrome
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated