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Contribution of viral mimics of cellular genes to KSHV infection and disease.
[primary effusion lymphoma]
Kaposi
's
sarcoma
-associated
herpesvirus
(
KSHV
,
also
named
Human
herpesvirus
8
HHV-
8
)
is
the
cause
of
Kaposi
sarcoma
(
KS
)
,
the
most
common
malignancy
in
HIV-infected
individuals
worldwide
,
primary
effusion
lymphoma
(
PEL
)
and
multicentric
Castleman
disease
(
MCD
)
.
KSHV
is
a
double
-stranded
DNA
virus
that
encodes
several
homologues
of
cellular
proteins
.
The
structural
similarity
between
viral
and
host
proteins
explains
why
some
viral
homologues
function
as
their
host
counterparts
,
but
sometimes
at
unusual
anatomical
sites
and
inappropriate
times
.
In
other
cases
,
structural
modification
in
the
viral
proteins
can
suppress
or
override
the
function
of
the
host
homologue
,
contributing
to
KSHV-related
diseases
.
For
example
,
viral
IL
-
6
(
vIL-
6
)
is
sufficiently
different
from
human
IL
-
6
to
activate
gp
130
signaling
independent
of
the
α
subunit
.
As
a
consequence
,
vIL-
6
can
activate
many
cell
types
that
are
unresponsive
to
cellular
IL
-
6
,
contributing
to
MCD
disease
manifestations
.
Here
,
we
discuss
the
molecular
biology
of
KSHV
homologues
of
cellular
products
as
conduits
of
virus
/
host
interaction
with
a
focus
on
identifying
new
strategies
for
therapy
of
KS
and
other
KSHV-related
diseases
.
Diseases
Validation
Diseases presenting
"kshv-related diseases"
symptom
primary effusion lymphoma
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