Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems.

[primary effusion lymphoma]

Human herpesvirus 8 (HHV 8 )-associated lymphomas are uncommon , mainly affect men infected with the human immunodeficiency virus (HIV ), and usually have a poor prognosis . We sought to characterize the HHV 8 + lymphomas seen at our institution since the mid-1990 s .We identified 15 patients with HHV 8 -associated lymphomas and evaluated their clinical and pathologic features .Diagnoses included primary effusion lymphoma (PEL ) (n = 2 ), extracavitary PEL (n = 8 ), intravascular large B-cell lymphoma (n = 1 ), HHV 8 + plasmablastic microlymphoma (n = 3 ), and germinotropic lymphoproliferative disorder (GLD ) (n = 1 ). The case of GLD progressed to a high -grade HHV 8 + Epstein-Barr virus-positive lymphoma , an evolution that has not been previously reported . Four patients were HIV-(three from an HHV 8 -endemic area ). Potentially misleading pathologic features in our series of extracavitary PEL included classic Hodgkin lymphoma -like features , lymph node sinus involvement , and T -cell antigen expression .H HV 8 -associated lymphomas can be clinically and pathologically heterogeneous , with features that may lead to misdiagnosis as other types of lymphoma .

Diseases
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Diseases presenting "an evolution that has not been previously reported" symptom

primary effusion lymphoma

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