Primary liposarcoma of the mediastinum.

[pleomorphic liposarcoma]

Patient . A 62 -year -old man presented with effort dyspnea , non-productive cough and weakness of 4 month duration . He had no findings on physical examination .Discussion . Chest X-ray revealed a large mass in the left anterior mediastinum . Computerized tomography of the chest showed a well-delineated homogeneous mediastinal mass with fat-equivalent density and a small pleural effusion . Fiberoptic bronchoscopy revealed narrowing of the left main bronchus , secondary to external compression . The bronchial mucosa was normal and brush cytology was negative . A CT -guided fine needle aspiration (FNA ) of the mass yielded fragments of cells embedded in myxoid background material and closely packed atypical lipoblasts , compatible with liposarcoma . The patient underwent a left lateral thoracotomy and margibnal resection of the mass . The histopathological examination confirmed the diagnosis of mixed -type liposarcoma , consisted of myxoid and pleomorphic liposarcoma . Postoperative two -field radiation therapy was delivered to the mediastinum for a total midplane dose of 40 Gy . After a disease-free interval of 8 months the disease recurred in the mediastinum and pleura . Palliative chemotherapy achieved a short duration partial response but the patient succumbed to local recurrence 2 years after the diagnosis .

Diseases
Validation

Diseases presenting "dyspnea" symptom

acute rheumatic fever

allergic bronchopulmonary aspergillosis

carcinoma of the gallbladder

congenital diaphragmatic hernia

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

erdheim-chester disease

esophageal carcinoma

fabry disease

familial mediterranean fever

inclusion body myositis

liposarcoma

lymphangioleiomyomatosis

neuralgic amyotrophy

pleomorphic liposarcoma

primary effusion lymphoma

scrub typhus

systemic capillary leak syndrome

thoracic outlet syndrome

well-differentiated liposarcoma

This symptom has already been validated