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Added Value of Molecular Biological Analysis in Diagnosis and Clinical Management of Liposarcoma: A 30-Year Single-Institution Experience.
[pleomorphic liposarcoma]
Treatment
decisions
and
prognosis
assessment
for
liposarcoma
is
based
on
a
classification
that
depends
on
morphological
and
genetic
features
.
Revisions
by
experienced
referral
pathologists
are
often
advocated
.
The
process
of
histopathological
classification
in
referring
hospitals
and
subsequently
in
a
referral
center
in
relation
to
molecular
biological
information
is
evaluated
.
A
total
of
331
consecutive
liposarcoma
patients
were
evaluated
for
the
added
value
of
histological
review
at
time
of
referral
.
Subsequently
,
cases
were
reclassified
with
implementation
of
present-
day
molecular
information
.
For
all
patients
,
complete
data
on
staging
,
treatment
,
and
follow-up
were
available
.
Upon
histological
revision
,
15
/
54
(
28
%
)
diagnoses
were
reclassified
in
the
first
decade
,
14
/
65
(
22
%
)
in
the
second
,
and
14
/
53
(
26
%
)
in
the
last
decade
.
Molecular
biological
analysis
enabled
well-differentiated
liposarcoma
with
or
without
dedifferentiated
component
to
be
better
recognized
as
such
and
distinguished
from
myxoid
liposarcoma
and
pleomorphic
liposarcoma
.
Inclusion
of
cytogenetic
information
resulted
in
reclassification
after
revision
in
4
/
18
(
22
%
)
cases
in
the
first
decade
,
10
/
38
(
26
%
)
cases
in
the
second
decade
,
and
19
/
75
(
25
%
)
cases
in
the
last
decade
.
This
study
indicates
that
liposarcomas
are
heterogeneous
tumors
.
Expert
assessment
and
implementation
of
molecular
biological
analysis
are
valuable
for
adequate
classification
as
a
basis
for
treatment
decisions
.
