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Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature.
[pleomorphic liposarcoma]
Pleomorphic
liposarcoma
(
PLPS
)
is
a
rare
,
high
-grade
sarcoma
defined
by
the
presence
of
pleomorphic
lipoblasts
.
Constituting
5
%
of
all
liposarcomas
,
PLPS
usually
arises
in
deep
soft
tissues
of
the
extremities
,
with
rare
occurrences
in
the
dermis
and
subcutis
.
We
describe
a
unique
case
of
an
85
-
year
-old
Caucasian
gentleman
with
a
1
year
history
of
a
pedunculated
,
pink
,
non-tender
papule
on
the
dorsum
of
his
left
arm
,
measuring
1
.
0
cm
in
maximum
dimension
.
Biopsy
revealed
a
dermal
collection
of
atypical
epithelioid
and
spindle
cells
superimposed
on
a
sclerotic
background
,
resembling
a
pleomorphic
fibroma
on
low
power
.
On
high
power
,
a
central
focus
of
discrete
adipocytic
differentiation
with
pleomorphic
lipoblasts
was
present
.
Tumor
cells
were
positive
for
S-
100
and
negative
for
desmin
,
actin
,
CD
68
,
keratin
,
MART
-
1
and
CD
34
.
Clinicopathologic
findings
were
consistent
with
PLPS
and
the
diagnosis
was
made
.
PLPS
is
rarely
localized
to
the
dermis
and
one
with
low
power
features
resembling
a
pleomorphic
fibroma
has
not
been
previously
described
in
the
literature
.
Diseases
Validation
Diseases presenting
"a central focus of discrete adipocytic differentiation with pleomorphic lipoblasts was present"
symptom
pleomorphic liposarcoma
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