Challenging epithelioid mesenchymal neoplasms: mimics and traps.

[pleomorphic liposarcoma]

Epithelioid mesenchymal malignancies represent a major diagnostic challenge . Epithelioid morphology can be observed in a variety of soft tissue neoplasms , however there exist specific subtypes in which an epithelioid apperance constitutes the most distinctive morphological feature . Moving from epithelioid sarcoma of Enzinger (the prototype of sarcoma with epithelioid morphology ), this review will focus on the most relevant entities : namely epithelioid haemangioendothelioma and angiosarcoma , pseudomyogenic haemangioendothelioma , epithelioid malignant peripheral nerve sheath tumour , epithelioid sclerosing fibrosarcoma , epithelioid pleomorphic liposarcoma , alveolar soft part sarcoma , and undifferentiated soft tissue sarcoma with epithelioid morphology . Differential diagnoses and major pitfalls will be discussed in detail .