Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Our Team
Prevention and control of Hb Bart's disease in Guangxi Zhuang Autonomous Region, China.
[alpha-thalassemia]
To
demonstrate
the
performance
of
Hb
Bart
's
Disease
prevention
in
Guangxi
Zhuang
Autonomous
Region
,
China
.
A
prenatal
control
program
for
Hb
Bart
's
disease
was
conducted
from
January
2006
to
December
2012
.
A
total
of
17
,
555
pregnant
women
were
screened
for
α-thalassemia
in
our
prenatal
screening
program
.
Pregnancy
at
-risk
for
Hb
Bart
's
disease
was
offered
the
choice
of
direct
invasive
testing
or
the
non-invasive
approach
with
serial
ultrasonography
.
A
total
of
1425
at
-risk
couples
attended
the
prenatal
diagnosis
.
Three
hundred
ninety
couples
were
screened
at
our
own
hospital
,
and
the
remaining
1035
couples
were
referred
from
other
hospitals
.
Two
hundred
and
three
pregnant
women
chose
non-invasive
approach
,
and
1122
chose
invasive
testing
.
A
total
of
365
fetuses
were
diagnosed
with
Hb
Bart
's
disease
.
All
cases
were
finally
confirmed
by
fetal
DNA
analysis
.
Eighty
-
two
cases
(
22
.
4
%
)
were
diagnosed
by
chorionic
villous
sampling
and
194
(
53
.
2
%
)
by
amniocentesis
samples
.
The
other
89
(
24
.
4
%
)
cases
were
performed
by
cordocentesis
.
All
of
the
affected
pregnancies
were
terminated
.
Implementation
of
a
prevention
and
control
program
accompanying
with
a
referral
system
for
prenatal
diagnosis
is
technically
feasible
in
Guangxi
Zhuang
Autonomous
Region
,
China
.
